Researchers from the National Center for Food Safety Risk Assessment in Beijing, China, said researchers have found more nutrients from stevioside, including non-glycoside diterpenes, chlorogenic acids, flavonoids and Vitamins and so on.

However, the latest study also shows that stevioside extract on tumor cells antioxidant and anti-proliferative effect than diterpene glucoside stronger.

In order to assess the toxicity of stevia, the researchers conducted a large number of experiments in vitro and in vivo. The study recorded a negative effect of bacterial reverse mutation analysis, mouse bone marrow micronucleus test and mouse sperm abnormality analysis. Studies have shown that the oral drink concentration of 1.04%, 2.08%, and 3.12% of the stevia extract did not cause behavioral, hematological, clinical or histopathological changes in rats over a 90-day period. In addition, no significant differences in food intake and body weight were observed between the test and control groups during the 90-day study without death or treatment-related adverse outcomes.

Researchers tested long-term oral stevia extract from female rats in the highest dose group and showed a significant reduction in cholesterol, protein and albumin levels in rats.

Stevia extract of stevia extract showed that both genotoxic and chronic oral toxicity did not reach 300 times the recommended daily intake. Scientific research data demonstrate the safety of the stevioside bioactive ingredient, so it can act as a functional active ingredient in functional foods and nutritional supplements.