A recent study by the University of Baylor in the United States shows that the patented turmeric extract of BCM-95 curcumin is more effective than standard curcumin in reducing colitis disease activity and inflammation, and the results of this study have been published in the journal Science.
In this study, the researchers conducted animal model tests on the effects of two turmeric extracts on colitis, with 95% standard curcumin and BCM-95, respectively. Among them, turmeric extract BCM-95 86% pure curcumin compounds and turmeric oil mixed together, the essential oil mixture also contains 45% of the patented components AR-turmerones.
In the study, all mice were enrolled in standard curcumin or BCM-95 at a dose of 5 mg, 25 mg or 50 mg / kg for more than 1 week. After that, the standard curcumin or BCM-95 group continued to take about 1 week of dextran sodium sulfate (DSS) to induce colitis. Finally, the researchers compared the treatment group and the untreated group with a disease activity index (ADI) to assess the severity of the daily disease.
Researchers evaluated the colon length, body weight, fecal hardness, visual blood in feces, and also evaluated the inflammatory markers. The study showed that BCM-95 slows DAI (P <0.001) for daily disease, and the degree of alleviation of the disease increases with increasing doses (25 mg and 50 mg / kg) Seventh day). The colon length of BCM-95 group was slowed down, while the standard curcumin group did not show any change. In addition, BCM-95 can significantly increase the inflammatory gene, up-regulation of anti-inflammatory markers such as IL-10 and IL-11, and standard curcumin group of inflammatory markers did not significantly improve.
In another trial, the researchers found that the synergistic effect of the raw materials in BCM-95 increased the bioavailability of curcumin, including 45% essential oil source components AR-turmerones and 86% curcumin. In addition, it was also found that turmeric extract in the turmeric extract and curcumin synergistic use can enhance its anti-inflammatory and antioxidant effects.
At present, BCM-95 has been the US FDA's GRAS certification, and has 12 patents, a number of companies such as the European pharmaceutical and Life Extension with its other functional ingredients mixed together to play a synergistic effect, thereby improving bioavailability The