A recent study by researchers at the Taipei Medical University in our country found that polyphenols contained in grape extract can inhibit senile cognitive disorders caused by high-fat high fructose (HFHF) diet-induced oxidative damage and hyperglycemia.
In this randomized study, the researchers fed an eight-week-old mouse with an HFHF diet and continued for 66 weeks to induce a type II diabetes disorder in mice. Subsequently, the mice were divided into four groups, one group was still fed HFHF diet, the second group was HFHF diet with 3% grape powder (LGP group), the third group was HFHF diet with 6% grape powder (HGP group) , The fourth group in the HFHF diet added metformin. The results showed that 6% of the grape powder could significantly reduce the expression of advanced glycated terminal receptor (RAGE) and superphosphorylation of TAU protein in brain tissue, and regulate the expression of Nrf2 and BDNF, and regulate the expression of PI3K And ERK phosphorylation.
Studies have long been shown to increase the expression of BDNF and Nrf2 as key to brain function. BDNF can play a key role in learning and memory by maintaining the plasticity of neuronal synapses, while Nrf2 can prevent oxidative damage to the brain by regulating the expression of antioxidant proteins.
Researchers say long-term high-fructose, high-fat diets can cause hyperglycemia-related cognitive disorders, and grape powder supplements help delay brain damage associated with neurodegeneration. The addition of grape powder to the HFHF diet inhibits brain hyperphosphorylation and other signaling pathways that cause cognitive impairment in the brain, improving the learning and cognitive ability of older rats.